I faced this issue yesterday,it was very strange because it doesn't make sense at all.
I have a master page and 1 content page,in that content page there is only one TextBox and an Ajax Editor (from ASP.NET AJAX Control Toolkit),no more no less.
I tried to run the page but the debugger doesn't compile at all,it keeps showing this error message:
After a long analysis at the source/html of my page and trying every possibility I finally found what caused the issue that I won't guess it at all:
EMPTY TITLE for my content page
That is what caused the issue,I was surprised,after removing/setting a value for the title the problem solved!
I hope my experience with this issue might help someone else,if anyone face the same issue and solved it in the same way or in a different way then please post it here,this will surely help others as well.