Trying VS10 in a minimal theme works out well.
Rob Connerys Vibrant Ink theme with the toolbox and navigation windows removed, you can find it here.
Folks use VS in different ways, taking a cue from Jimmy Boguard who runs VS as follows.
As Jimmy notes in his blog post the lack of navigation windows and tool bars, in many respects Jimmy uses VS like a text editor but as he states
Since I’m writing code 99% of the time I’m in an IDE, my experience should be optimized for writing code.
As an IDE VS can be used in many different ways and everyone has different views on what is and what is not an optimized experience. Could VS be better at that saving away your chosen experince and allowing you to share that between machines\pc's etc? Could VS offer by default more experinces and the ability to better share those experiences?