Trying VS10 in a minimal theme works out well.
Rob Connerys Vibrant Ink theme with the toolbox and navigation windows removed, you can find it here.
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Remove the blue space around the editor, make the tabs smaller, remove the dropdowns for code navigation and you get a really minimalistic editor :) BTW: I hope there will be a way to get rid of that blue background -- totally useless -- and make the tabs a bit smaller.
You can also remove the useless line numbers. The current line number is already available in the status bar (with the column number).
