Situation:
Your buddy has created a cool VB.NET application that you want to use.  He sends you the source code and it consists of a solution (MySolution) containing a single project (MyProject).  You attempt to open the solution and find that it has SourceSafe dependencies.  You need to remove all the VSS stuff from the solution/project files.

Solution:

1 - Go to the folder containing the solution files and delete the following:
          mssccprj.scc
          MyProject.vssscc
          vssver.scc

2 - Open MyProject.sln in your favorite text editor and remove the following section:
          GlobalSection(SourceCodeControl) = preSolution
                     ...
          EndGlobalSection

3 - Go to the folder containing the project files and delete the following:
          MyProject.vbproj.vspscc
          mssccprj.scc
          vssver.scc

4 - Open MyProject.vbproj in your text editor and remove the following lines:
          SccProjectName = "SAK"
          SccLocalPath = "SAK"
          SccAuxPath = "SAK"
          SccProvider = "SAK"

Now you can open the solution/project with no source control errors.