ASP.NET 1.x Error Message: Access is Denied
Sometimes, I randomly get an error when developing ASP.NET apps saying that access is denied to some assembly in my bin directory. Specifically under C:\Windows\Microsoft.NET\Framework\v1.1.4322\Temporary ASP.NET Files.
A local guy I know from our user group (and work we've done for their company), Jeremy Diller, found the answer for me. It turns out that it's the Indexing Service freaking out ASP.NET and seemingly locking files. This answer is gold! Saved me a ton of (continuing) frustration.