Articulate Engage
It's official. 
We just shipped our first desktop product coded from the ground up on top of the .NET Framework: Engage (http://www.articulate.com/engage.html). Engage lets you create Flash based interactions. It's pretty slick for rapidly creating compelling training content. Check it out and let me know what you think.
[1] Engage Product Information
http://www.articulate.com/engage.html
[2] Rapid eLearning Studio Product Information
http://www.articulate.com/studio.html
[3] Official Blog Post:
http://blog.articulate.com/create-interactive-content-for-elearning-courses/