Add this awesome FAQ by Dave Wanta to your bookmarks.
All about Sending email in .NET 2.0
If you're still a .NET 1.x user, see here http://www.systemwebmail.com/
About JoeStagner
Joe Stagner is a Senior Program Manager in Microsoft Corporation’s Developer Tools and Platform Group and has been with Microsoft since 2001 focusing on highly scalable and performant web application architectures, multiplatform interoperability and software security. Joe brings 30 years technical and business strategy experience to Microsoft which affords him a unique experiential perspective.