Fast Python on the CLR
IronPython Here's the performance data from December 2003. IronPython really shows that Jim Hugunim is doing an excellent job and that ActiveState got it completely wrong. All we need now is the download.
Update Based on Joel Pobar's blog about LCG, Jason Zander and Brad Abrams comments, maybe Python (and other dynamic languages) are the next big change coming down the line. I know from an investment banks perspective, Python is used in a small number of trading systems - just search JobServe for 'python and bank'