Tip: Temporarily Disable Snaplines
The .NET 2.0 Forms Designer has an awesome new feature called Snaplines. Snaplines show visual cues to help you line up controls on a form. They make it very easy to conform to the Windows User Interface Guidelines.
But if you're in a situation where you want percise control over placement of a control, simply hold down the ALT key while you're dragging. The snaplines don't appear and the control won't try to "snap" itself into one of the potential alignment positions.