In a previous post, Before it becomes famous, I posted about S#, or SmallScript, a SmallTalk variant that was being designed that was supposed to have a version that might have worked on .NET. Now, it seems that project has pretty much died out. David Simmons, the main figure behind S#, now works for Microsoft. His role there does not seem to allow much priority for S#. Here is S# - Smalltalk :: The Next Generation, an interview with him that explains his current assignment. In that article, he projected a date for the next release of S# as "out in the fall," but that was in 2006.
So, I'm not seeing or hearing much,if anything, going on in the S# or SmallScript worlds. My conclusion is that it appears the project is dead. I still have hope that someone will develop a decent SmallTalk implementation for .NET. If you see one, please let me know!