One of the top reported Microsoft Connect issues with VS 2010 has been an issue with the Find and Replace dialog – which grows 16px each time you use it (which is pretty annoying).
Hope this helps,
P.S. A few people reported issues installing the patch if they had an older version of the Silverlight 4 tools installed. If you see an error message that says you need an update to Visual Studio to support Silverlight 4, you can fix it by installing the latest Silverlight 4 tools release.